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R&D Systems™ Go 6976

Product Code. 18094722
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Quantity:
500 μg
Unit Size:
500µg
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Product Code. Quantity Unit Size
18094722 500 μg 500µg
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Product Code. 18094722 Supplier R&D Systems™ Supplier No. 2253/500U
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    282.00€
    266.70€ / 500µg
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Estimated Shipment: 30-10-2026
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Description

A Tocris product, part of R&D Systems. Potent protein kinase C inhibitor; selective for α and β isozymes

Go 6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.
TRUSTED_SUSTAINABILITY

Specifica

Chemical Name or Material 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
CAS 136194-77-9
Quantity 500 μg
Product Line Tocris
Target Protein Kinase C Inhibitors
Molecular Formula C24H18N4O
Purity 95%
Titolo del prodotto
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