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Gibco™ Human Gremlin-1 Recombinant Protein, PeproTech®

Product Code. 17891543
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10 μg
100 μg
2 x 500 μg
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500 μg
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1mg
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50µg
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Product Code. Quantity unitSize
17891543 100 μg 100µg
17860193 10 μg 10µg
30088758 2 x 500 μg Pack of 2
17841053 2 x 500 μg 1mg
17840973 250 μg 250µg
17890573 500 μg 500µg
17880873 50 μg 50µg
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Product Code. 17891543 Supplier Gibco™ Supplier No. 12042100UG

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Description

Recombinant Protein

120-42-1MG will be provided as 2 x 500 μg (120-42-500UG). Recombinant Human Gremlin-1 is a 18.3 kDa protein containing 160 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O60565
For Use With (Application) Control, Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 26585
Molecular Weight (g/mol) 18.3 kDa
Name Human Gremlin-1
Purification Method Purified
Quantity 100 μg
Source CHO cells
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias C15DUPq; Cell proliferation-inducing gene 2 protein; CKTSF1B1; colorectal adenoma and carcinoma 1; CRAC1; CRCS4; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; DAND2; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Drm; DUP15q; Grem; GREM1; gremlin; gremlin 1; gremlin 1 homolog, cysteine knot superfamily; gremlin 1, cysteine knot superfamily, homolog; gremlin 1, DAN family BMP antagonist; gremlin 1-like protein; gremlin-1; HMPS; HMPS1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2; ld; MPSH; PIG2
Common Name GREM1
Gene Symbol Grem1
Biological Activity Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 ug/ml
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Content And Storage -20°C
Activity Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 ug/ml.
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 90% by SDS-PAGE gel and HPLC analyses.
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