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IL-12/IL-23 p40 Monoclonal Antibody (C8.6), Functional Grade, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 16-7129-025
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Description
Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits. Applications Reported: The C8.6 antibody has been reported for use ELISA, ELISPOTand neutralization. Applications Tested: The Functional Grade Purified C8.6 antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA detection and in bioassay for neutralization of IL-12 p70 and IL-23 bioactivity. The C8.6 antibody at 60.0 ng/mL has been found to inhibit by 50% the biological effects of 1 ng/mL human IL-12 p70 (14-8129) or human IL-23 (14-8239), in corresponding bioassay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols® section. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.
IL-12/IL-23 p40 Monoclonal antibody specifically detects IL-12/IL-23 p40 in Human samples. It is validated for ELISA, Functional Assay, Neutralization
Specifications
| IL-12/IL-23 p40 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| P29460, Q9NPF7 | |
| Mouse | |
| 25 mg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| ELISA, Functional Assay, Neutralization | |
| C8.6 | |
| Functional Grade | |
| Il23a | |
| CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 40 kDa subunit; il 12; IL 12/IL 23p40; il 23; IL 23 p40; Il12; IL-12 subunit p40; IL12, subunit p40; IL12B; IL-12B; IL12p40; Il-12p40; il23; IL-23; IL23 p41; IL-23 subunit alpha; Il23a; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; IMD28; IMD29; Interleukin; Interleukin 12; interleukin 12 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12, p40; interleukin 12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin 23 p19 subunit; interleukin 23 subunit alpha; Interleukin 23, alpha subunit p19; Interleukin12; interleukin-12 beta chain; interleukin-12 p40; interleukin-12 p40 subunit; interleukin-12 subunit beta; interleukin-23 p19 subunit; interleukin-23 p40 subunit; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2; p19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798 | |
| Affinity chromatography | |
| RUO | |
| 3593, 51561 | |
| 4° C | |
| Liquid |
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