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Invitrogen™ IL-22 Receptor alpha Monoclonal Antibody (496504)
Rat Monoclonal Antibody
Brand: Invitrogen™ MA561416
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
Specifications
| IL-22 Receptor alpha | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q80XZ4 | |
| Il22ra1 | |
| Mouse myeloma cell line NS0-derived recombinant mouse IL-22 R alpha 1, Thr18-Ala228. | |
| 100 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG2a |
| Western Blot | |
| 496504 | |
| Unconjugated | |
| Il22ra1 | |
| 9130219A07Rik; CRF2-9; Cytokine receptor class-II member 9; cytokine receptor family 2 member 9; ENSMUSG00000073746; il-22 receptor; IL-22 receptor subunit alpha-1; IL22R; IL-22R; IL22R1; IL22RA1; IL-22RA1; IL-22R-alpha-1; ILN; Interleukin; interleukin 22 receptor subunit alpha 1; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; interleukin-22 receptor subunit alpha-1; RGD1559655; zcytoR11 | |
| Rat | |
| Protein A/G | |
| RUO | |
| 230828 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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