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Invitrogen™ IL4R Monoclonal Antibody (25463)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA523814
This item is not returnable.
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Description
In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha, rhIL-5 R beta, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.
Specifications
| IL4R | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 5% trehalose and No Preservative | |
| P24394 | |
| IL4R | |
| Sf 21-derived recombinant human IL-4 R Gly24-His232. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Flow Cytometry, Immunohistochemistry (Paraffin), Neutralization, Western Blot, Immunocytochemistry | |
| 25463 | |
| Unconjugated | |
| IL4R | |
| 582J2.1; CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL4-BP; Il4r; IL4R nirs variant 1; IL-4R subunit alpha; IL4RA; IL-4RA; IL-4R-alpha; interleukin 4 receptor; interleukin 4 receptor, alpha; interleukin-4 receptor alpha chain; interleukin-4 receptor subunit alpha; Soluble IL-4 receptor subunit alpha; Soluble interleukin-4 receptor subunit alpha | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 3566 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Lyophilized |
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