missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. STEMCELL Technologies IQ-1

STEMCELL Technologies IQ-1

Product Code. 17140122
Encompass_Preferred
Click to view available options
Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
This item is not returnable. View return policy

Product Code. 17140122

Brand: STEMCELL Technologies 72772

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

WNT pathway activator; Inhibits protein phosphatase PP2A

  • IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin
  • IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription (Miyabayashi et al.)
  • Used with Wnt3a to maintain pluripotency of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblasts (MEFs), serum, or exogenous leukemia inhibitory factor (LIF; Miyabayashi et al.)
  • Enhances expansion of mouse ES-derived cardiovascular progenitor cells (Schenke-Layland et al.)
  • Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drug resistance and tumorigenicity (He et al.)

Specifications

CAS 331001-62-8
Quantity 5 mg
Molecular Formula C21H22N4O2
Purity ≥98%
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.