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ITGB3BP Monoclonal Antibody (OTI4H1), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA803458
This item is not returnable.
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Description
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.Specifications
| ITGB3BP | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q13352 | |
| ITGB3BP | |
| Full length human recombit protein of human ITGB3BP produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI4H1 | |
| Unconjugated | |
| ITGB3BP | |
| CENP-R, CENPR, HSU37139, NRIF3, TAP20 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 23421 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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