Epredia™ Lab Vision™ Calponin-1 Rabbit Monoclonal Antibody

Description

Calponin, a thin filament associated protein, is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34 kDa and 29 kDa. Expression of the 29 kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.

Host Species: Rabbit

Clone: EP798Y

Species Reactivity: Human. Others not known.

Immunogen: A synthetic peptide derived from near the C-terminus of human Calponin-1

Molecular Weight: 29/34 kDa

Positive Control: Breast CA

Cellular Localization: Cytoplasm Myoepithelial cells

Recommended for:

• Immunohistochemistry (Formalin/paraffin)