Thermo Scientific™ Lab Vision™ CDX2, Rabbit Monoclonal Antibody
Ensure accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ CDX2, Rabbit Monoclonal Antibody.
Brand: Thermo Scientific™ RM-2116-S0
Additional Details : Weight : 0.00170kg
Ensure accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ CDX2, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio. Studies show rabbit monoclonal antibodies are more sensitive and specific than other available markers.The caudal-related homeodomain protein2 (CDX2) is a transcription factor shown to play a role in the development of small and large intestine in mammals and in the differentiation of intestinal epithelial cells. It has been shown that CDX2 protein detection by IHC coorelates with RNA transcript levels. In studies using 745 cancers from many anatomic sites, colonic adenocarcinomas demonstrated strong staining in 90% of the cases, while adenocarcinomas of the stomach, esophagus and ovary showed extensive staining in only 30% of the cases. Stains of CDX2 and Villin are useful markers in differntial diagnosis of bladder adenocarcinoma and secondary colorectal adenocarcinoma.
Host Species: Rabbit
Species Reactivity: Human. Others not tested.
Ig Isotype: Rabbit IgG
Epitope: not determined
Immunogen: A synthetic peptide corresponding to residues near the N-terminus of human CDX2
Molecular Weight: 40 kDa
Positive Control: Colon carcinomas
Cellular Localization: Nuclear with occasional cytoplasmic staining on colon carcinoma
- Immunohistochemistry (Formalin/paraffin)
|A synthetic peptide corresponding to residues near the N-terminus of human CDX2|