Epredia™ Lab Vision™ CDX2 Rabbit Monoclonal Antibody

Description

The caudal-related homeodomain protein2 (CDX2) is a transcription factor shown to play a role in the development of small and large intestine in mammals and in the differentiation of intestinal epithelial cells. It has been shown that CDX2 protein detection by IHC coorelates with RNA transcript levels. In studies using 745 cancers from many anatomic sites, colonic adenocarcinomas demonstrated strong staining in 90% of the cases, while adenocarcinomas of the stomach, esophagus and ovary showed extensive staining in only 30% of the cases. Stains of CDX2 and Villin are useful markers in differntial diagnosis of bladder adenocarcinoma and secondary colorectal adenocarcinoma.

Host Species: Rabbit

Clone: EPR2764Y

Species Reactivity: Human. Others not tested.

Ig Isotype: Rabbit IgG

Epitope: not determined

Immunogen: A synthetic peptide corresponding to residues near the N-terminus of human CDX2

Molecular Weight: 40 kDa

Positive Control: Colon carcinomas

Cellular Localization: Nuclear with occasional cytoplasmic staining on colon carcinoma

Recommended for:

• Immunohistochemistry (Formalin/paraffin)