Epredia™ Lab Vision™ COX2 Rabbit Monoclonal Antibody

Description

COX2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

Host Species: Rabbit

Clone: SP21

Isotype: IgG

Species Reactivity: Human, Mouse and Rat. Others not tested.

Epitope: C-terminus

Immunogen: A synthetic peptide from C-terminus of rat COX2

Molecular Weight: 70 kDa

Positive Control: Lung and colon CAs

Cellular Localization: Cytoplasmic and membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)