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Melanoma Associated Antigen (PNL2) Antibody (PNL2), Novus Biologicals™
Mouse Monoclonal Antibody
Brand: Novus Biologicals NBP2-45284-0.1MG
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Description
Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Immunofluorescence
Melanoma Associated Antigen (PNL2) Monoclonal specifically detects Melanoma Associated Antigen (PNL2) in Human, Canine samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
Specifications
| Melanoma Associated Antigen (PNL2) | |
| Monoclonal | |
| 0.2mg/mL | |
| Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml | |
| Mouse | |
| Protein A or G purified | |
| RUO | |
| Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF. | |
| Store at 4C. | |
| IgG1 |
| Immunohistochemistry (Paraffin), SDS-Page, Immunofluorescence | |
| PNL2 | |
| Unconjugated | |
| 10mM PBS and 0.05% BSA with 0.05% Sodium Azide | |
| Melanocyte antigen | |
| 0.1 mg | |
| Primary | |
| Human, Mouse, Canine | |
| Purified |
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