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  8. Methyl trifluoroacetate, 98+%

Methyl trifluoroacetate, 98+%

Product Code. 11453577
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Product Code. 11453577 Supplier Thermo Scientific Alfa Aesar Supplier No. A17338.18
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Description

CAS: 431-47-0 | C3H3F3O2 | 128.05 g/mol

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

Solubility
Not miscible or difficult to mix in water.

Notes
Moisture sensitive. Store away from strong bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 431-47-0
Molecular Formula C3H3F3O2
Molecular Weight (g/mol) 128.05
MDL Number MFCD00000417
InChI Key VMVNZNXAVJHNDJ-UHFFFAOYSA-N
Synonym methyl trifluoroacetate, trifluoroacetic acid methyl ester, acetic acid, trifluoro-, methyl ester, methyltrifluoroacetate, 2,2,2-trifluoromethylacetate, acetic acid, 2,2,2-trifluoro-, methyl ester, methyl trifluoracetate, tfamt, methyl triflouroacetate, pubchem12490
PubChem CID 9893
IUPAC Name methyl 2,2,2-trifluoroacetate
SMILES COC(=O)C(F)(F)F

Specifications

Melting Point -78°C
Density 1.283
Boiling Point 43°C to 44°C
Flash Point −18°C (−0.4°F)
Odor Pungent
Refractive Index 1.29
Quantity 50 g
UN Number UN2924
Beilstein 1756070
Sensitivity Moisture sensitive
Solubility Information Not miscible or difficult to mix in water.
Formula Weight 128.05
Percent Purity ≥98%
Chemical Name or Material Methyl trifluoroacetate
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Safety and Handling

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Product Identifier
  • Methyl trifluoroacetate
 Signal Word
  • Danger
 Hazard Category
  • Serious eye damage/eye irritation Category 1
  • Flammable liquid Category 2
  • Skin corrosion/irritation Category 1 B
 Hazard Statement
  • H225-Highly flammable liquid and vapour.
  • H314-Causes severe skin burns and eye damage.
  • H318-Causes serious eye damage.
 Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P240-Ground/bond container and receiving equipment.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
 Supplemental information
  • MIXTURE LIST-Contain: Methyl trifluoroacetate
SDS

RUO – Research Use Only

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