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Invitrogen™ mGluR8 Monoclonal Antibody (476410)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561539
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Specifications
| mGluR8 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| O00222 | |
| GRM8 | |
| Chinese hamster ovary cell line CHO-derived recombinant human mGluR8, Gln34-Ser514 (predicted). | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Immunohistochemistry (Paraffin), Western Blot | |
| 476410 | |
| Unconjugated | |
| GRM8 | |
| A230002O04; FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; GLUR8; glutamate metabotropic receptor 8; glutamate receptor; glutamate receptor, metabotropic 8; Gprc1h; Grm8; M mGlu8; Metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; MGC126724; mGlu8; mGlur; mGluR8; mGluR8b | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 2918 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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