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  5. Tocris Bioscience™ ML 323

Tocris Bioscience™ ML 323
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Product Code. p-7139262
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25 mg
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Product Code. Quantity unitSize
18781408 5 mg 5mg
18701748 25 mg 25mg
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Product Code. 18781408 Supplier Tocris Bioscience™ Supplier No. 6435/5

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Description

Potent and selective USP1-UAF1 allosteric inhibitor

ML 323 is a potent and selective allosteric inhibitor of USP1-UAF1 deubiquitinase complex (IC50 = 76 nM). Exhibits selectivity for USP1-UAF1 over a panel of enzymes, including other deuquitinating enzymes. Inhibits deubiquitination of PCNA and FANCD2 and sensitizes cisplatin-resistant H596 cells to cell death induced by cisplatin (Cat. No. 2251) in vitro.
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Specifications

CAS 1572414-83-5
Synonym 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
Quantity 5 mg
Molecular Formula C23H24N6
Formula Weight 384.48
Purity 98%
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