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Necrostatin-1

Product Code. 15446849
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Product Code. 15446849 Supplier Thermo Scientific Alfa Aesar Supplier No. J65341.F+
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Description

CAS: 4311-88-0 | C13H13N3OS | 259.327 g/mol

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe
TRUSTED_SUSTAINABILITY

Especificaciones

CAS 4311-88-0
Color Yellow
Molecular Formula C13H13N3OS
MDL Number MFCD00056916
Quantity 20 mg
Sensitivity Light sensitive
Synonym necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
Solubility Information Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml).
InChI Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
Molecular Weight (g/mol) 259.327
PubChem CID 2828334
Formula Weight 259.33
Physical Form Powder
Chemical Name or Material Necrostatin-1
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