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Tocris Bioscience™ NF 449
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Product Code. 18024812
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Product Code. 18024812 Supplier Tocris Bioscience™ Supplier No. 1391/10

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Description

Highly selective P2X1 antagonist

NF 449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. Also inhibits DNA-binding activity of HMGA2 (IC50 = 0.43 μM).

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 627034-85-9
Molecular Formula C41H27N6Na5O29S8

Specifications

Quantity 10 mg
Formula Weight 1505.06
Purity 90%
Molecular Weight (g/mol) 1439.109
Chemical Name or Material NF 449
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