Invitrogen™ NKG2H Monoclonal Antibody (633810)

Description

Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.

NKG2H is a gene that encodes a protein belonging to the NKG2 family of receptors, which are expressed primarily on natural killer (NK) cells and some subsets of T cells. The NKG2 family members, including NKG2H, play crucial roles in the regulation of immune responses, particularly in the recognition and elimination of infected or transformed cells. NKG2H is an activating receptor that, upon binding to its ligands, can stimulate NK cell cytotoxic activity and cytokine production, thereby enhancing the immune response against tumors and viral infections. The ligands for NKG2H are typically stress-induced molecules that are upregulated on the surface of diseased cells, making this receptor pivotal in immune surveillance. Understanding the specific functions and signaling pathways of NKG2H is important for developing therapeutic strategies aimed at boosting NK cell activity in cancer immunotherapy and antiviral treatments. Research into NKG2H also contributes to a broader understanding of immune regulation and the potential for manipulating NK cell responses to improve clinical outcomes in various diseases.