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Invitrogen™ NOTCH3 Recombinant Rabbit Monoclonal Antibody (1A7L4)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA557979
This item is not returnable.
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Description
Immunogen sequence: PAAGAHSSPP KARFLRVPSE HPYLTPSPES PEHWASPSPP SLSDWSESTP SPATATGAMA TTTGALPAQP LPLSVPSSLA QAQTQLGPQP EVTPKRQVLA.
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Specifications
| NOTCH3 | |
| Recombinant Monoclonal | |
| 1.32 mg/mL | |
| PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| Q9UM47 | |
| Notch3 | |
| A synthetic peptide corresponding to a sequence within amino acids 2222-2321 of human NOTCH3 (NP_000426.2). | |
| 20 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
| ELISA, Western Blot | |
| 1A7L4 | |
| Unconjugated | |
| Notch3 | |
| AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3 | |
| Rabbit | |
| Protein A | |
| RUO | |
| 4854 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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