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P-Glycoprotein Monoclonal Antibody (F4), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA513854
Additional Details : Weight : 0.01000kg
Description
MA5-13854 targets p170 in FACS, WB and ICC/IF applications and shows reactivity with Hamster and Human samples. This antibody does not react with mouse tissue in Western blot applications. The MA5-13854 immunogen is human and hamster drug-resistant viable cells followed by crude plasma membranes.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.Specifications
| P-Glycoprotein | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 | |
| P08183, P21448, P21449 | |
| ABCB1, Abcb1b | |
| Human and hamster drug-resistant viable cells followed by crude plasma membranes | |
| 500 μL | |
| Primary | |
| Hamster, Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunocytochemistry, Western Blot | |
| F4 | |
| Unconjugated | |
| ABCB1 | |
| ABC superfamily; P-glycoprotein; ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; ATP binding cassette subfamily B member 1; ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette transporter subfamily B, member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, subfamily B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B, member 1A; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; ATP-dependent translocase ABCB1; multidrug r | |
| Mouse | |
| Protein G | |
| RUO | |
| 100682536, 100682537, 5243 | |
| 4° C | |
| Liquid |