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DiscoverX PathHunter™ U2OS RANK NF-kB Signaling Pathway Reporter Cell Line

Product Code. 17324429
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Quantity:
2 Vials
Unit Size:
2 ampoules
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17324429 2 Vials 2 ampoules
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Product Code. 17324429 Supplier DiscoverX Supplier No. 931156C3

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Description

The PathHunter™ U2OS RANK NF-kB Pathway Reporter Cell Line measures RANK NF-kB pathway activation through detection of induced expression levels of a tagged reporter protein. This cell line ships as two vials of cryopreserved cells.

The PathHunter™ U2OS RANK NF-kB Pathway Reporter Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting the RANK NF-kB pathway. This cell line enables assessment of RANK NF-kB pathway stimulation based on changes in the expression of a RANK NF-kB response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a RANK NF-kB pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Transcriptional Reporter
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist soluble RANKL
Quantity 2 Vials
Accession Number NM_003839.3
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