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Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI) Acylation Reagents

Conduct acylation of hydroxyl groups and primary and secondary amines with the Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI).

Brand:  Thermo Scientific™ TS-48882

Additional Details : Weight : 0.20000kg Transport : UN number : 1993 Chem class : 3 Pack group : III

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Product Code. 11747067

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.


Description

Description

Conduct acylation of hydroxyl groups and primary and secondary amines with the Thermo Scientific™ Perfluoroacylimidazoles (TFAI and HFBI). Compared to acid chlorides and anhydrides, the reactions of fluorinated acylimidazoles are smooth and quantitative, and produce no acid byproducts. The principal byproduct is imidazole, which is relatively inert. The volatile and stable fluoroacyl derivatives are ideal for FID and electron-capture detection (ECD) techniques.

Applications

Used in bifunctional derivatization schemes and in exchange reactions in which TMS derivatives are converted to HFB derivatives.

Hydroxyl groups of catecholamines are derivatized with TMSI, followed by conversion of the amines to acylamides with HFBI.

Tryptamine and metabolites present in spinal fluid have been analyzed by ECD using HFBI.

Specifications

Specifications

2°C to 8°C
1-(Trifluoroacetyl)-1 H-imidazole
Corrosive, Flammable
TFAI; 10 x 1 mL ampules
FID, ECD
10 x 1 mL Ampules
98 to 100%
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For Research Use Only. Not for use in diagnostic procedures.