missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ PF 5274857 hydrochloride

Tocris Bioscience™ PF 5274857 hydrochloride
GREENER_CHOICE

Product Code. 18734729
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18734729

Brand: Tocris Bioscience™ 5262/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

High affinity and selective Smoothened (Smo) receptor antagonist

PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 50 mg
Product Type PF 5274857 hydrochloride
Purity >98%
Molecular Weight (g/mol) 473.42
Inhibitors PF 5274857 hydrochloride

For Research Use Only

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.