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Phospho-Tyrosine Hydroxylase (Ser19) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538240
Additional Details : Weight : 0.00900kg
Description
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson′s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.Specifications
Phospho-Tyrosine Hydroxylase (Ser19) | |
Polyclonal | |
Unconjugated | |
TH | |
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, TYH | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
21823, 25085, 7054 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P07101, P24529, P04177 | |
TH | |
A synthetic phosphopeptide derived from human TyrHydroxylase around the phosphorylation site of Ser19 (A-V-SP-E-Q) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |