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Tocris Bioscience™ Picropodophyllotoxin
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Product Code. 18772484
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10 mg
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Product Code. 18772484 Supplier Tocris Bioscience™ Supplier No. 2956/10

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Description

Selective IGF1R inhibitor

Orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ∽ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
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Specifications

CAS 477-47-4
Quantity 10 mg
Molecular Formula C22H22O8
Formula Weight 414.41
Purity >97%
Molecular Weight (g/mol) 414.41
Chemical Name or Material Picropodophyllotoxin
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