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Invitrogen™ PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (24GB885)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA557174
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Description
PKC alpha/beta/gamma Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
Specifications
| PKC alpha/beta/gamma | |
| Recombinant Monoclonal | |
| 2 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P05129, P05132, P05771, P17252, P27791, P63318, P63319, P68403, P68404 | |
| PRKACA, PRKCB, PRKCG | |
| A synthesized peptide derived from human PKC (aa 300-500). | |
| 20 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB885 | |
| Unconjugated | |
| PRKACA | |
| A130082F03Rik; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit C alpha; Cs-PKA; PKA C-alpha; Pkaca; PKC; PKCA1; Pkcb; PKC-B; PKC-beta; PKCC; PKCD; PKCG; PKCgamma; PKC-gamma; PKCI; PPNAD4; PRKACA; Prkc; Prkcb; Prkcb1; Prkcb2; Prkcc; Prkcg; protein kinase A; protein kinase A alpha; protein kinase A catalytic subunit; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, gamma; protein kinase cAMP-activated catalytic subunit alpha; protein kinase, cAMP dependent, catalytic, alpha; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; RATPKCI; SCA14; sperm cAMP-dependent protein kinase catalytic subunit | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 18747, 18751, 18752, 24681, 25023, 25636, 5566, 5579, 5582 | |
| -20°C | |
| Liquid |
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