missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Cell Culture Media, Supplements, and Reagents
  4. Cell Culture Reagents, Antibiotics and Supplements
  5. Antibiotics
  6. Melford Plicamycin

Melford Plicamycin

Product Code. 30018682
Change view
Click to view available options
Quantity:
1 mg
5 mg
Unit Size:
1mg
5mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
30018682 5 mg 5mg
30018681 1 mg 1mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Product Code. 30018682 Supplier Melford Supplier No. P303000.005

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Plicamycin, also known as mithramycin or Mithracin, is an antineoplastic antibiotic produced by the bacterium Streptomyces plicatus.

Plicamycin, also known as mithramycin or Mithracin, is an antineoplastic antibiotic produced by the bacterium Streptomyces plicatus. Plicamycin binds to DNA and inhibits both DNA and RNA synthesis. It accomplishes this by binding to the guanine-cytosine (GC) rich regions of DNA, preventing the transcription of genetic information into RNA. As a result, the synthesis of proteins and other essential cellular components is disrupted.

Plicamycin inhibits the activity of osteoclasts, the cells responsible for breaking down bone tissue. Also, it interferes with the function of certain transcription factors, such as Sp1 (specificity protein 1). Transcription factors are proteins that regulate the transcription of genes. By disrupting the activity of transcription factors, plicamycin affects the expression of genes involved in cell growth and differentiation.

Researchers may employ plicamycin to investigate its effects on gene expression, cell cycle regulation, and apoptosis in cancer cells.

Specifications

Chemical Name or Material Plicamycin
CAS 18378-89-7
Quantity 5 mg
Molecular Formula C52H76O24
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.