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RCAN2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 12900-1-AP-20UL
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Description
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin′s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.Specifications
| RCAN2 | |
| Polyclonal | |
| Unconjugated | |
| RCAN2 | |
| Calcipressin 2, CSP2, DSCR1L1, hRCN2, MCIP2, RCAN2, regulator of calcineurin 2, ZAKI 4, ZAKI4 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 10231, 53901 | |
| -20°C | |
| Liquid |
| Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation | |
| 0.13 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q14206, Q9JHG2 | |
| Rcan2 | |
| RCAN2 Fusion Protein Ag3597 | |
| 20 μL | |
| Primary | |
| Mouse, Human | |
| Antibody | |
| IgG |
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