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SETD7 Monoclonal Antibody (OTI2E3), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA503377
This item is not returnable.
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Description
Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.Specifications
| SETD7 | |
| Monoclonal | |
| 0.31 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q8VHL1, Q8WTS6 | |
| SETD7 | |
| Full length human recombit protein of human SETD7 produced in HEK293 cell. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Western Blot | |
| OTI2E3 | |
| Unconjugated | |
| SETD7 | |
| KMT7, SET7, SET7/9, SET9 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 73251, 80854 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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