missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ SHISA4 Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5149189
This item is not returnable.
View return policy
Description
Reconstitute at 0.2 mg/mL in sterile PBS.
SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
Specifications
| SHISA4 | |
| Polyclonal | |
| Unconjugated | |
| SHISA4 | |
| 9330132O05Rik; C1orf40; mShisa4; Protein shisa-4; shisa family member 4; shisa homolog 4; SHISA4; Tmem58; transmembrane protein 58; UNQ583/PRO1153 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 149345, 77552 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q8CA71, Q96DD7 | |
| SHISA4 | |
| E. coli-derived recombinant human Shisa-4, Glu29-Thr85. | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction