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Invitrogen™ SIGIRR Monoclonal Antibody (162201)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA562056
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
Specifications
| SIGIRR | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| Q6IA17 | |
| SIGIRR | |
| Mouse myeloma cell line NS0-derived recombinant human SIGIRR, Met1-His118. | |
| 500 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Western Blot | |
| 162201 | |
| Unconjugated | |
| SIGIRR | |
| AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8; UNQ301/PRO342 | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 59307 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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