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  6. SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™, Invitrogen™
  7. 17170992

SIGLEC H Monoclonal Antibody (eBio440c), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-0333-025

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Product Code. 17170992

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Description

Description

The MAb eBio440c recognizes Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.

SIGLEC H Monoclonal antibody specifically detects SIGLEC H in Mouse samples. It is validated for Flow Cytometry, Functional Assay
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Specifications

Specifications

SIGLEC H
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
6430529G09Rik; sialic acid binding Ig-like lectin H; Siglec; Siglech; Siglec-H; SIGLEC-like protein
Affinity chromatography
RUO
233274
4° C
Liquid
Flow Cytometry, Functional Assay
eBio440c
Functional Grade
Siglech
Rat
25 mg
Primary
Mouse
Antibody
IgG2b κ
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