Ambion™ Silencer™ Select Pre-Designed siRNA

The Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry. A choice of Silencer™ Select siRNAs are available—Pre-Designed or Validated. Silencer™ Select Pre-Designed siRNAs are guaranteed-to-silence based on their proven design while the Silencer™ Select Validated siRNAs are functionally tested to reduce target gene expression. Sets of Silencer™ Select siRNA Libraries are also available in tubes or plate for high throughput screening. The Silencer™ Select Positive and Negative Control RNAs should be included in every siRNA experiment.

The benefits of using Silencer™ Select siRNAs include:

Potent—up to 100-fold more potent than currently available siRNAs and fewer off-target effects

Most Specific—LNA™ chemical modifications reduce off-target effects by up to 90%

Reliable—demonstrated improvements in consistency and reliability of phenotypic results

Guaranteed—100% guaranteed to silence, the best guarantee in the industry

Note: Silencer™ Pre-Designed & Validated siRNAs are designed using our first-generation algorithm and DO NOT include any chemical modifications. They are recommended for completing in vitro RNAi studies that were started using Silencer™ siRNAs. For new studies we recommend Silencer Select siRNAs.

Approximate Turnaround Times*

Standard purification: 4 business days

HPLC purification: 6 business days (20 and 40 nmol); 15 business days (250 nmol)

In Vivo Ready: 15 business days (250 nmol)