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  5. Tocris Bioscience™ SP 600125

Tocris Bioscience™ SP 600125
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Product Code. 18095862
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
Product Code. Quantity unitSize
18095862 10 mg 10mg
18095572 50 mg 50mg
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Product Code. 18095862

Brand: Tocris Bioscience™ 1496/10

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Description

Selective JNK inhibitor

SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions. SP 600125 protects renal tubular epithelial cells from ischemia/reperfusion-induced apoptosis. Promotes chondrogenesis of bone mesenchymal stem cells by inhibition of TNF-α-induced inflammation. Adipogenesis from MSCs is also promoted by SP 600125. Essential component of medium for maintaining stem cells in naive pluripotent state.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 129-56-6
Molecular Formula C14H8N2O

Specifications

Quantity 10 mg
Formula Weight 220.23
Purity >98%
Molecular Weight (g/mol) 220.231
Chemical Name or Material SP 600125
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