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STEMCELL Technologies SP600125

Product Code. 17120102
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Quantity:
5 mg
Unit Size:
5mg
Product Code. Quantity unitSize
17120102 5 mg 5mg
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Product Code. 17120102

Brand: STEMCELL Technologies 72642

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Description

JNK pathway inhibitor; Inhibits JNK1, JNK2, and JNK3

  • SP600125 is a potent and reversible inhibitor of JNK1-3 (IC50 = 0.11 μM) (Bennett et al.) It is cell-permeable and dose-dependently inhibits c-JUN phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN- in T-cells (Bennett et al.)
  • Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, Gö6983, VaLproic Acid and Y-27632 (Hu et al.)
  • Inhibits BMP9-induced osteogenic differentiation in cultured mouse mesenchymal stem cells (MSCs) and in primary bone marrow stromal cells (Zhao et al.)
  • Promotes adipogenic, but represses osteogenic differentiation of human MSCs (Bilkovski et al.; Liu et al.; Qiu et al.; Tominaga et al.)
  • Causes cell death and inhibits neurogenesis when added during early stages of neuronal culture (Tiwari et al.)

Specifications

CAS 129-56-6
Synonym NSC 75890; Pyrazolanthrone; 1PMV
Quantity 5 mg
Molecular Formula C14H8N2O
Purity ≥98%
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