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SPRTN Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Thermo Scientific PA555226
Additional Details : Weight : 0.02000kg
Description
Immunogen sequence: SHQNVLSNYF PRVSFANQKA FRGVNGSPRI SVTVGNIPKN SVSSSSQRRV SSSKISLRNS SKVTESASVM PSQDVSGSED T Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 55%.
SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.Specifications
| SPRTN | |
| Polyclonal | |
| Unconjugated | |
| SPRTN | |
| C1orf124; DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DVC1; Gm505; PRO4323; protein with SprT-like domain at the N terminus; RGD1559496; spartan; sprT-like domain-containing protein Spartan; SprT-like N-terminal domain; Sprtn; UNQ1880/PRO4323; zinc finger RAD18 domain-containing protein | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 83932 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry | |
| 0.3 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q9H040 | |
| SPRTN | |
| Recombinant protein corresponding to Human SPRTN | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Research Use Only