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SPRTN Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5110424
Additional Details : Weight : 0.01000kg
Description
Immunogen sequence: MDDDLMLALR LQEEWNLQEA ERDHAQESLS LVDASWELVD PTPDLQALFV QFNDQFFWGQ LEAVEVKWSV RMTLCAGICS YEGKGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV TNNDKDREGH GPEFCKHMHR INSLTGANIT VYHTFHDEVD EYRRHWWRCN GPCQHRPPYY GYVKRATNRE PSAHDYWWAE HQKTCGGTYI KIKEPENYSK KGKGKAKLGK EPVLAAENKG
SPRTN is a regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.Specifications
| SPRTN | |
| Polyclonal | |
| Unconjugated | |
| SPRTN | |
| C1orf124; DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DVC1; Gm505; PRO4323; protein with SprT-like domain at the N terminus; RGD1559496; spartan; sprT-like domain-containing protein Spartan; SprT-like N-terminal domain; Sprtn; UNQ1880/PRO4323; zinc finger RAD18 domain-containing protein | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 83932 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot | |
| 0.63 mg/mL | |
| PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
| Q9H040 | |
| SPRTN | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SPRTN (NP_001010984.1). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |