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  8. Tamoxifen citrate

Tamoxifen citrate

Product Code. 15423639
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5 g
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Product Code. 15423639 Supplier Thermo Scientific Alfa Aesar Supplier No. J60955.06
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Description

Inhibitor of protein kinase C and induces apoptosis in cancer cells | CAS: 54965-24-1 | C32H37NO8 | 563.65 g/mol

Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tamoxifen citrate is used as an antiestrogen with potent anti-cancer and PKC inhibitory activities. Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.

Solubility
Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 54965-24-1
Molecular Formula C32H37NO8
Molecular Weight (g/mol) 563.65
MDL Number MFCD00058321
InChI Key FQZYTYWMLGAPFJ-OQKDUQJOSA-N
Synonym tamoxifen citrate, istubal, zitazonium, unii-7frv7310n6, i.c.i. 46474 citrate, tamoxifen citrate salt, farmifeno, ginarsan, jenoxifen
PubChem CID 2733525
ChEBI CHEBI:9397
IUPAC Name (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine; 2-hydroxypropane-1,2,3-tricarboxylic acid
SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O.CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1

Specifications

Color White
Quantity 5 g
Sensitivity Hygroscopic; Light sensitive
Merck Index 14,9048
Solubility Information Soluble in methanol (50mg/ml with heat) or ethanol (10mg/ml with sonication); very slightly soluble in water (0.3mg/L @ 20°C; the pH is approximately 3.0-3.5),0.02 N HCl (0.2mg/ml @ 37°C)4,acetone ,chloroform,and DMSO(100mM)
Formula Weight 563.65
Physical Form Powder
Chemical Name or Material Tamoxifen citrate

Safety and Handling

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Product Identifier
  • Tamoxifen citrate
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 4
  • LONG-TERM AQUATIC HAZARD Chronic 1
  • ACUTE AQUATIC Acute 1
  • Carcinogenicity Category 1A
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H302-Harmful if swallowed.
  • H350-May cause cancer.
  • H360-May damage fertility or the unborn child.
  • H400-Very toxic to aquatic life.
  • H410-Very toxic to aquatic life with long lasting effects.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P264-Wash face, hands and anyexposed skin thoroughly after handling.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contain: Tamoxifen citrate
SDS

RUO – Research Use Only

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