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Thomsen-Friedenreich Antigen Antibody (SPM320), Novus Biologicals™

Product Code. 18171559 Shop All Bio Techne Products
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Product Code. 18171559 Supplier Novus Biologicals Supplier No. NBP2452820.1MG

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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Immunofluorescence

Thomsen-Friedenreich Antigen Monoclonal specifically detects Thomsen-Friedenreich Antigen in Human, Mouse, Rat samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Thomsen-Friedenreich Antigen
Applications Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone SPM320
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Host Species Mouse
Immunogen Neuraminidase-treated human red blood cells
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. This MAb is capable to agglutinate desialylated red blood cells. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.
Target Species Human, Mouse, Rat
Content And Storage Store at 4C.
Form Purified
Isotype IgM κ
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