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Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody,Lab Vision™ Epredia™
Provide accurate, reproducible results Epredia™ Thymidylate Synthase Ab-1, Mouse Monoclonal Antibody.
Brand: Epredia MS-471-P
Additional Details : Weight : 0.00250kg
Description
Thymidylate Synthase (TS) (EC 2.1.1.45) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Host Species: Mouse
Clone: TS 106
Isotype: IgG1/κ
Species Reactivity: Human. Others not known.
Epitope: Not determined
Immunogen: Recombinant human TS enzyme
Molecular Weight: 36kDa
Positive Control: 5-FU-resistant cell cancer lines or colon CA
Cellular Localization: Nuclear and cytoplasmic
Recommended for:
- Western Blotting
- Immunofluorescence
- Immunoprecipitation (Native verified)
- ELISA
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| Thymidylate Synthase Ab-1 | |
| Monoclonal | |
| 200μg/mL | |
| Mouse | |
| 1 mL | |
| DNA Repair | |
| Human | |
| IgG2a κ |
| Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot | |
| TS 106 | |
| Unconjugated | |
| Recombinant human TS enzyme | |
| RUO | |
| Primary | |
| Concentrated |