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  8. Tolbutamide, 98%

Tolbutamide, 98%

Product Code. 11460287
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Product Code. 11460287 Supplier Thermo Scientific Alfa Aesar Supplier No. B21698.09
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Description

CAS: 64-77-7 | C12H18N2O3S | 270.347 g/mol

Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.

Solubility
Soluble in chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 64-77-7
Molecular Formula C12H18N2O3S
Molecular Weight (g/mol) 270.347
MDL Number MFCD00027169
InChI Key JLRGJRBPOGGCBT-UHFFFAOYSA-N
Synonym tolbutamide, orinase, 1-butyl-3-tosylurea, tolbutamid, aglicid, arkozal, artosin, diabetol, dolipol, rastinon
PubChem CID 5505
ChEBI CHEBI:27999
IUPAC Name 1-butyl-3-(4-methylphenyl)sulfonylurea
SMILES CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Specifications

Melting Point 128°C to 130°C
Quantity 10 g
Beilstein 1984428
Merck Index 14,9507
Solubility Information Soluble in chloroform.
Formula Weight 270.35
Percent Purity 98%
Chemical Name or Material Tolbutamide

Safety and Handling

compliance-icons
Product Identifier
  • Tolbutamide
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Skin sensitiser Category 1
 Hazard Statement
  • H302-Harmful if swallowed.
  • H317-May cause an allergic skin reaction.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contain: Tolbutamide
SDS

RUO – Research Use Only

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