Invitrogen™ TRAF3 Isoform 2 Monoclonal Antibody (433113)

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

TRAF3 Isoform 2 is a variant of the TNF receptor-associated factor 3 (TRAF3) gene, which plays a crucial role in the regulation of immune responses, inflammation, and cell survival. TRAF3 is a part of the TRAF protein family, which mediates signal transduction from various receptors of the TNF receptor superfamily, Toll-like receptors (TLRs), and other immune receptors. Isoform 2 of TRAF3 may have distinct regulatory functions compared to the canonical form, potentially influencing specific signaling pathways. TRAF3 is known to act as a negative regulator of the non-canonical NF-kappaB signaling pathway, which is important for immune homeostasis and prevention of chronic inflammation. Alterations or mutations in TRAF3, including its isoforms, have been associated with various diseases, including autoimmune disorders, lymphomas, and other cancers. Research into TRAF3 Isoform 2 could provide insights into its unique roles and therapeutic potential in modulating immune responses and treating related diseases.