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TWIST1 Monoclonal Antibody (3E1), Invitrogen™
Mouse Monoclonal Antibody
Brand: Thermo Scientific MA532927
This item is not returnable.
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Description
TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
Specifications
| TWIST1 | |
| Monoclonal | |
| Unconjugated | |
| TWIST1 | |
| Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWIST | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 22160, 7291 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| 3E1 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
| P26687, Q15672 | |
| Twist1 | |
| Purified recombit fragment of human TWIST1 (AA: 9-74) expressed in E. Coli. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
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