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STEMCELL Technologies Vandetanib

Product Code. 17110242
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10 mg
Unit Size:
10mg
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17110242 10 mg 10mg
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Product Code. 17110242 Supplier STEMCELL Technologies Supplier No. 73532

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Description

Tyrosine kinase inhibitor; Inhibits VEGFR1, KDR, FLT-4, EGFR, FGFR, ABL, RET, and SRC

  • Vandetanib is a multi-kinase inhibitor targeting primarily receptor tyrosine kinases, such as vascular endothelial growth factor receptors (VEGFR1, KDR, and FLT4), epidermal growth factor receptor (EGFR), and fibroblast growth factor receptor (FGFR; Morabito et al.) It most potently inhibits KDR with an IC50 of 40 nM
  • It also inhibits non-receptor tyrosine kinases such as RET, ABL, and SRC as well as several serine/threonine kinases (Carlomagno et al.; Hennequin et al.; Kiselyov et al.; Levinson & Boxer)
  • Inhibits tumor growth in mouse xenograft models, including RET/PTC papillary thyroid carcinoma and lung carcinoma (Hennequin et al.; Carlomagno et al.)
  • Inhibits angiogenesis, cell growth, and metastasis in numerous cancer cell lines (Morabito et al.; Wedge et al.)

Spécification

CAS 443913-73-3
Synonym CH 331; ZD 6474; Zactima
Quantity 10 mg
Molecular Formula C22H24BrFN4O2
Purity ≥98%
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