Invitrogen™ Viral MIP-III Monoclonal Antibody (76621)

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

MIP-III, also known as CCL28 (C-C motif chemokine ligand 28), is a chemokine gene that plays a significant role in the immune system by directing the migration of immune cells to sites of inflammation and infection. The protein encoded by MIP-III is a member of the CC chemokine family and is primarily expressed in mucosal tissues such as the intestines, lungs, and mammary glands. MIP-III is known to attract a variety of immune cells, including T cells, B cells, and eosinophils, by binding to its receptors CCR3 and CCR10. This chemokine is involved in the mucosal immune response, helping to maintain immune surveillance and protect against pathogens. Additionally, MIP-III has been implicated in the pathogenesis of inflammatory diseases and allergic reactions due to its role in recruiting immune cells to affected tissues. Understanding the function and regulation of MIP-III is important for developing therapeutic strategies aimed at modulating immune cell trafficking in conditions such as inflammatory bowel disease, asthma, and other mucosal inflammatory disorders. Research into MIP-III also provides insights into the mechanisms of immune cell migration and the potential for targeting chemokines in immunotherapy.