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Invitrogen™ XRCC4 Monoclonal Antibody (5C10)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA524383
This item is not returnable.
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Description
The antibody detects endogenous XRCC4 proteins.
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
Specifications
| XRCC4 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4 | |
| Q13426, Q924T3 | |
| XRCC4 | |
| Recombinant Protein of Human XRCC4. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG1 |
| Immunoprecipitation, Western Blot | |
| 5C10 | |
| Unconjugated | |
| XRCC4 | |
| 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4 | |
| Mouse | |
| Antigen affinity chromatography | |
| RUO | |
| 108138, 7518 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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