Invitrogen™ Yellow Fever Virus NS5 (strain 17D vaccine) Recombinant Rabbit Monoclonal Antibody (HL2916)

Description

Yellow Fever Virus NS5 (strain 17D vaccine) Recombinant Monoclonal Antibody for Western Blot

The NS5 protein of the Yellow Fever Virus (YFV) is the largest and most functionally diverse non-structural protein, playing a pivotal role in viral replication and transcription. This multifunctional protein possesses both RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) activities, which are essential for the synthesis and capping of viral RNA. The RdRp activity of NS5 is responsible for copying the viral RNA genome, while the MTase activity adds a cap to the viral RNA, which is crucial for RNA stability and translation. Additionally, NS5 interacts with various host cell factors to modulate immune responses, aiding in viral evasion and persistence. Due to its critical functions in the viral life cycle, NS5 is a prime target for antiviral drug development. Inhibiting NS5 can potentially disrupt viral replication and reduce viral load, making it a key focus for therapeutic intervention. Ongoing research aims to elucidate the detailed mechanisms of NS5's activities and interactions, which could lead to the development of effective antiviral agents against yellow fever and other flavivirus-related diseases.