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  5. R&D Systems™ Yoda 1

R&D Systems™ Yoda 1

Product Code. 18775866
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Product Code. 18775866 Supplier R&D Systems™ Supplier No. 5586/10
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Description

A Tocris product, part of R&D Systems. Piezo1 channel activator

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
CAS 448947-81-7
Quantity 10 mg
Product Line Tocris
Target Other Calcium Channel Activators
Molecular Formula C13H8Cl2N4S2
Formula Weight 355.27
Purity >99%
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