Invitrogen™ Annexin A6 Recombinant Rabbit Monoclonal Antibody (7X4H2)

Description

Immunogen sequence: DDDAAGQFF PEAAQVAYQM WELSAVARVE LKGTVRPAND FNPDADAKAL RKAMKGLGTD EDTIIDIITH RSNVQRQQIR QTFKSHFGRD LMTDLKSEIS GDLARLILGL MMPPAHYDAK QLKKAMEGAG TDEKALIEIL ATRTNAEIRA INEAYKEDYH KSLEDALSSD TSGHFRRILI SLATGHREEG GENLDQARED AQVAAEILEI ADTPSGDKTS LETRFMTILC TRSYPHLRRV FQEFIKMTNY DVEHTIKKEM SGDVRDAFVA IVQSVKNKPL FFADKLYKSM KGAGTDEKTL TRIMVSRSEI DLLNIRREFI EKYDKSLHQA IEGDTSGDFL KALLALCGGE D.

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.