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CD8 Mouse anti-Human, APC-H7, Clone: SK1, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 560273
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Description
CD8 recognizes the 32kDa a-subunit of a disulfide-linked bimolecular complex. The majority of peripheral blood CD8+ T lymphocytes express an a/b heterodimer (Mr 32, 30kDa), while CD8+CD16+ natural killer (NK) lymphocytes and CD8+ T-cell receptor (TCR)-γ/δ+ lymphocytes express a/a homodimer (Mr 30kDa). CD8+TCR-α/β+ lymphocytes can express either an α/α homodimer or α/β heterodimer. The CD8 antigenic determinant binds to class I major histocompatibility (MHC) molecules resulting in increased adhesion between the CD8+ T lymphocytes and target cells. Binding of the CD8 antigen is coupled to a protein tyrosine kinase p56lck. The CD8:p56lck complex can play a role in T-lymphocyte activation through mediation of the interactions between the CD8 antigen and the CD3/TCR complex.
Host Species: Mouse
Clone: SK1
Isotype: IgG1 κ
Species Reactivity: Human
Immunogen: Human Peripheral Blood T Cells
Flow Cytometry
Specifications
| CD8 | |
| Monoclonal | |
| APC-H7 | |
| Aqueous buffered solution containing BSA, protein stabilizer, and ≤0.09% sodium azide. | |
| Human Peripheral Blood T Cells | |
| 25 Tests | |
| Immunology | |
| Baboon, Cynomolgus, Human, Rhesus Monkey | |
| IgG1 κ |
| Flow Cytometry | |
| SK1 | |
| CD8α; CD8A; CD8 alpha; Leu2a; MAL; T8; p32 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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