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CD16 Mouse, anti-Human, FITC, Clone: 3G8, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 60041FI.1
This item is not returnable.
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Description
- The 3G8 antibody reacts with CD16 (FcγRIII or low affinity IgG receptor III), a type 1 transmembrane glycoprotein belonging to the Ig superfamily
- CD16 exists in two distinct isoforms: CD16a, a 50 - 65 kDa form expressed on NK cells, activated monocytes, macrophages, and placental trophoblasts, and CD16b, an ∼48 kDa glycosylphosphatidylinositol (GPI)-anchored form expressed on neutrophils, basophils and eosinophils and found as at least two polymorphic variants, termed NA1 and NA2
- CD16 binds weakly to the Fc region of monomeric, aggregated or complexed IgG, particularly the IgG1 and IgG3 isotypes
- Binding of IgG to either CD16 isoform induces signaling pathways that modulate several types of responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, cytokine release and proliferation
- CD16/IgG interactions can result in non-specific labeling in antibody-based detection and cell separation experiments
Specifications
| CD16 | |
| Monoclonal | |
| FITC | |
| 25 Tests | |
| Baboon, Cynomolgus, Chimpanzee, Human | |
| Granulocytes and Subsets, Monocytes |
| Immunohistochemistry, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| 3G8 | |
| Mouse | |
| Primary | |
| IgG1 κ |
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